############################################### # Logarithm of the 1-CodonPAM mutation matrix # # and the codon frequencies. # # Adrian Schneider, 2004 # ############################################### CodonLogPAM1:=[[-0.01043003, 0.00027692, 0.00337641, 0.00055551, 0.00076988, 1.0964e-05, 1.2569e-06, -1.0207e-05, 0.00234726, 0.00012061, 0.00061211, 0.00017251, 0.00070968, -7.4782e-06, 1.6621e-05, 1.7556e-05, 0.00086531, 7.7933e-05, 8.6086e-05, 7.6155e-05, 4.3088e-05, 1.7197e-05, 5.1847e-05, 1.1967e-05, 0.00024587, 0.00011596, 0.00035803, 0.00013892, 2.3157e-06, 2.043e-06, 4.101e-06, 1.9448e-05, 0.00109440, 1.4963e-05, -8.2766e-05, 5.8658e-05, 0.00027624, 9.1132e-06, -1.4448e-05, -5.7273e-07, 4.0851e-05, 3.0953e-06, 1.673e-06, 3.3032e-05, 0.00011042, 6.1295e-06, -5.0579e-06, 3.4859e-05, 0, 8.4677e-06, 0, 1.7286e-05, 3.1226e-05, 8.7698e-06, 2.8423e-06, 1.5169e-05, 0, 7.6911e-06, -3.8356e-06, 1.7847e-06, 5.3241e-05, 1.0636e-06, -2.371e-06, 5.7522e-06], [0.00029440, -0.01069626, 0.00041372, 0.00681585, 6.3184e-05, 0.00036704, 0.00012202, 0.00013938, 5.5101e-05, 0.00246189, 0.00023445, 8.9468e-05, 8.1669e-06, 0.00014696, 4.0551e-05, 2.3532e-05, 6.6317e-05, 0.00074501, 3.6966e-05, 2.1334e-05, 6.6738e-06, 6.6861e-05, 4.4966e-05, 4.9397e-06, 3.0932e-06, 0.00013152, 1.7159e-05, -2.9213e-05, -1.2439e-05, 2.9868e-05, 9.3953e-06, 2.4216e-05, 6.6018e-05, 0.00091943, 6.2832e-05, 4.4246e-05, -2.5689e-06, 0.00014849, -4.5157e-05, 1.4717e-05, 5.8911e-06, 0.00021250, 1.4667e-05, -1.8473e-06, 8.0127e-07, 4.5487e-05, -1.0633e-07, 1.7386e-05, 0, 0.00030219, 0, -3.3978e-05, 3.1201e-05, 5.5995e-05, 7.1011e-05, 1.1591e-05, 0, 4.3508e-05, 2.9493e-06, 2.2288e-06, -2.2263e-05, 3.459e-05, 1.6331e-05, -5.2396e-06], [0.00457225, 0.00052701, -0.00747460, 0.00046207, 6.7664e-05, 4.6394e-05, 0.00027666, 2.9863e-05, -0.00010418, 0.00012142, 0.00386561, 9.4317e-05, -7.5499e-05, 1.9564e-05, 0.00012942, 3.2508e-05, 9.1449e-05, 9.3422e-05, 0.00054636, 7.1713e-05, 1.5636e-05, 2.3819e-05, 5.2269e-05, 6.08e-06, 5.6042e-05, 0.00011423, 0.00070113, 0.00022285, 3.8256e-05, 5.7905e-06, 8.2458e-06, 7.8703e-06, -6.9525e-05, 5.1267e-05, 0.00049527, 2.8703e-05, -4.211e-05, 1.1119e-05, 0.00022892, 3.8369e-05, 1.034e-05, 2.0077e-05, 3.9145e-05, -1.56e-05, 7.4994e-05, 3.8912e-06, 3.6433e-05, 1.4054e-05, 0, 4.1727e-05, 0, 7.1293e-07, 2.396e-05, 1.2319e-05, 9.4374e-05, 7.7308e-06, 0, 7.0477e-06, 3.1572e-05, 7.9783e-07, 5.5179e-06, 1.4496e-07, 7.2235e-05, 4.3899e-07], [0.00037439, 0.00432260, 0.00022995, -0.01655247, 6.7126e-05, 2.513e-05, 8.2044e-06, 0.00077855, 7.315e-05, 0.00023007, 0.00024127, 0.00211333, 5.3157e-05, 1.3807e-05, 3.7093e-05, 0.00014208, 0.00012538, 0.00013103, 2.93e-05, 0.00056890, 2.1379e-05, 4.329e-05, -1.2603e-05, 1.6309e-05, 1.5508e-07, -2.1624e-05, 5.4644e-05, 0.00035457, 3.1498e-05, 2.9528e-06, -3.6785e-06, 7.1721e-05, 0.00016870, 6.8404e-05, 2.0249e-06, 0.00121800, 0.00016498, 2.4823e-05, 0.00027963, 4.6298e-05, 3.5644e-05, 4.4864e-05, 7.9777e-06, 0.00039548, -5.2928e-06, 6.6412e-06, -5.216e-06, 0.00016072, 0, 8.4212e-05, 0, 0.00033481, 2.0998e-05, 2.8328e-05, 7.5227e-05, 8.9001e-05, 0, 7.2619e-05, 3.8298e-05, 1.8747e-05, 1.7999e-05, 5.3047e-06, 4.2091e-05, 9.4671e-05], [0.00049904, 3.853e-05, 3.2391e-05, 6.455e-05, -0.01488560, 0.00103410, 0.00266818, 0.00330290, 0.00083750, 0.00015631, 2.9725e-05, 0.00010455, 0.00162957, 2.5358e-05, 0.00011360, 3.5252e-06, 0.00021312, 1.5475e-05, 4.5508e-06, 2.2963e-05, 0.00038258, 2.4522e-05, -2.6856e-05, -6.0057e-06, 1.1936e-05, 1.0591e-05, 2.4893e-06, -6.4428e-05, 0.00022972, -5.2279e-06, -1.4558e-05, 3.2834e-05, 0.00017362, 1.4084e-06, -1.7684e-06, 5.9828e-06, 0.00134562, -1.3775e-05, 0.00020026, -4.4117e-05, 5.8717e-05, 1.5589e-05, 1.3943e-06, -2.8185e-05, 0.00099709, 1.2224e-05, -5.4371e-06, 5.7616e-05, 0, 3.0592e-05, 0, -1.5258e-05, 0.00076274, 5.8695e-05, 0.00018402, 5.1267e-05, 0, 2.0199e-05, 3.8705e-06, 5.22e-06, 0.00043009, 9.5391e-06, 2.2612e-06, 1.3506e-06], [1.3395e-05, 0.00042196, 4.1868e-05, 4.5622e-05, 0.00194983, -0.00730210, 0.00127130, 0.00289566, 1.5811e-05, 0.00087276, 8.7505e-05, 0.00015224, 7.0783e-05, 0.00069919, 0.00010156, 0.00010509, 1.5444e-05, 8.6019e-05, 1.0071e-05, 1.072e-05, -4.9413e-06, 0.00036032, 3.9316e-05, 3.356e-06, -3.9755e-06, 6.5572e-05, 3.9511e-05, 4.2807e-05, 5.4116e-05, 9.9519e-05, 1.8661e-06, -1.4013e-05, 1.1249e-05, 9.9247e-05, 1.4719e-05, 7.5316e-06, -1.5508e-05, 0.00085087, -3.2084e-05, -4.2953e-05, 6.6323e-06, 3.7806e-05, -1.3184e-08, -1.7333e-06, 7.0072e-05, 0.00015550, 2.0608e-05, 0.00015364, 0, 0.00012276, 0, -7.0826e-06, 8.6957e-05, 0.00046108, 0.00013957, 4.0927e-05, 0, 8.5888e-05, 1.418e-05, 2.5317e-06, 4.73e-07, 6.0634e-05, 9.9421e-06, -9.5654e-06], [6.3239e-07, 5.772e-05, 0.00010273, 6.1234e-06, 0.00206989, 0.00052306, -0.00999512, 0.00153860, -2.8443e-05, 7.1615e-05, 0.00013609, 0.00012255, 0.00018282, 4.221e-05, 0.00034049, -4.9343e-05, -9.5628e-06, 1.7548e-05, 6.5865e-05, -9.1821e-07, 1.2631e-05, 1.0778e-05, 0.00031311, -2.9005e-05, -4.6493e-06, 5.522e-06, 5.9013e-05, -9.6386e-07, -7.3482e-05, -3.2193e-06, 7.8204e-05, -5.209e-06, 2.1367e-05, 2.1707e-05, 1.403e-05, 4.0909e-06, -0.00011014, 2.2281e-05, 0.00099514, -3.0547e-05, 6.63e-06, 4.8711e-06, 1.4045e-05, 6.8621e-06, 4.2602e-05, 2.6006e-05, 3.5385e-05, 2.3857e-05, 0, 1.1872e-05, 0, 5.8313e-06, 0.00011205, 4.5754e-05, 0.00079013, 1.3129e-05, 0, 7.6867e-06, 2.2179e-05, 3.5781e-06, 3.641e-05, 7.3159e-07, -5.0201e-05, 1.0736e-05], [-6.9842e-06, 8.9718e-05, 1.5095e-05, 0.00079071, 0.00348780, 0.00162267, 0.00209437, -0.01741139, 5.5748e-05, 0.00017321, 0.00011896, 0.00169335, -1.9354e-05, 7.6544e-05, 6.5513e-05, 0.00091768, 4.278e-05, 8.1723e-05, 1.5482e-05, 7.5697e-05, -3.0518e-05, 1.6098e-05, 4.6085e-05, 0.00051524, 5.6796e-05, -5.7482e-05, 3.4911e-05, 0.00055034, -1.1346e-05, 1.5518e-05, -1.2469e-06, 0.00015661, 2.1841e-05, 3.3911e-05, 5.0104e-06, 0.00025667, -6.1817e-05, 0.00012771, 0.00014150, 0.00137721, -1.2104e-05, 9.0493e-06, 3.3643e-06, 0.00046774, -6.2859e-05, 2.059e-05, 6.8415e-06, 0.00063615, 0, 1.0883e-05, 0, 0.00013012, 0.00011452, 0.00011364, 9.9615e-05, 0.00051716, 0, 9.3631e-06, 4.5386e-05, 3.1174e-05, 2.3831e-05, -1.003e-06, 4.6579e-05, 0.00010662], [0.00165221, 3.6487e-05, -5.4192e-05, 7.639e-05, 0.00090945, 9.108e-06, -3.9817e-05, 5.7322e-05, -0.00979720, 0.00016485, 0.00457354, 0.00045956, 0.00057044, 3.4227e-06, -3.4845e-08, -1.4168e-05, 0.00058838, 7.7198e-05, -2.088e-05, -4.8865e-07, -7.8399e-06, 4.9941e-06, 1.0023e-05, 7.1227e-06, 0.00214426, 0.00034289, 0.00100032, 0.00071310, 0.00021988, 6.6636e-07, -1.6935e-05, 1.2632e-07, 5.2129e-05, 2.8539e-06, -2.335e-06, -4.6708e-07, 0.00010666, 1.8759e-06, -2.0259e-05, -6.4659e-06, 0.00025269, 1.1801e-05, -3.5699e-05, -1.1144e-05, 2.3638e-05, 1.8376e-05, 4.7849e-06, 2.4296e-05, 0, 2.634e-06, 0, 5.1741e-06, -3.2346e-06, -2.3523e-06, -4.3971e-06, -1.0619e-06, 0, -4.6546e-06, 1.1256e-05, 6.2054e-06, 4.4082e-05, -4.6449e-07, 3.4163e-06, 7.6455e-06], [8.8707e-05, 0.00170316, 6.5942e-05, 0.00025156, 0.00017733, 0.00052522, 0.00010475, 0.00018642, 0.00017231, -0.01289116, 0.00050049, 0.00459301, 3.538e-05, 0.00014956, 2.6995e-05, 1.0087e-05, 3.4727e-05, 0.00028320, 2.6815e-05, 3.016e-05, 6.4565e-06, 0.00012486, 6.0101e-05, -1.4618e-05, 1.1703e-05, 0.00023348, 7.3032e-05, -0.00012492, 7.3297e-07, 7.0903e-05, 1.6898e-06, -1.0764e-05, 3.2326e-05, 0.00020489, 3.2158e-05, -8.7023e-06, 5.3366e-05, 0.00020226, 2.4401e-05, 4.8914e-05, 5.3979e-05, 0.00056798, 3.2312e-05, -2.1915e-05, 1.1134e-05, 2.9678e-05, 8.4548e-06, -2.8963e-05, 0, 8.6407e-05, 0, -1.5399e-05, 9.2403e-05, 0.00019478, 0.00016292, 0.00010310, 0, 0.00026316, 1.2148e-05, 5.7367e-06, -1.0278e-05, 7.4363e-05, 9.0887e-06, 6.2911e-06], [0.00023979, 8.6384e-05, 0.00111807, 0.00014021, 1.799e-05, 2.8044e-05, 0.00010600, 6.8067e-05, 0.00254432, 0.00026648, -0.01821711, 0.00044771, 0.00013250, 1.9186e-05, 7.9495e-05, 1.3019e-05, 2.3715e-05, 5.7289e-05, 2.6691e-05, 2.9864e-05, 1.2592e-05, 1.6039e-05, -5.1813e-05, -1.491e-06, 0.00045986, 0.00053633, 0.00383699, 0.00088549, -2.207e-05, 1.0962e-06, -2.5131e-06, 6.8659e-06, 1.4025e-05, 1.0544e-05, 4.1726e-05, 5.151e-05, 4.0863e-05, 2.7866e-05, 5.3293e-05, 4.7887e-07, 2.4877e-05, 2.0722e-05, 0.00023644, 1.455e-05, 8.9886e-05, 8.1494e-06, 1.6832e-05, -2.8837e-06, 0, 4.7365e-05, 0, 7.9186e-06, 1.5064e-05, 1.0155e-05, 2.4129e-05, -3.096e-06, 0, 2.9208e-06, 4.6328e-05, 7.8402e-06, 3.7121e-05, 1.6971e-05, 3.8717e-05, 6.0449e-06], [0.00012013, 5.8223e-05, 4.8505e-05, 0.00218363, 0.00011232, 8.6628e-05, 0.00016972, 0.00172277, 0.00045467, 0.00435301, 0.00079592, -0.01650501, 6.2207e-05, 1.8935e-06, 2.8932e-05, 0.00034125, 3.2391e-05, 2.0946e-05, 2.574e-05, 0.00023488, 4.0427e-06, 1.2647e-05, 9.0736e-05, 0.00014047, -7.0872e-06, -0.00019728, -3.8451e-05, 0.00183114, 8.9885e-06, 3.3259e-06, -1.544e-05, 0.00012833, 0.00013201, -1.2208e-05, -1.9939e-05, 0.00086837, 3.7738e-05, 1.7985e-05, 0.00020994, 0.00024087, 1.5035e-05, 1.3329e-05, 3.78e-05, 0.00211710, -2.8506e-05, 1.329e-05, -1.5285e-05, 0.00029866, 0, 3.0424e-05, 0, 0.00013522, 0.00019221, 8.0016e-05, 0.00022226, 0.00017151, 0, 5.8015e-05, 9.3929e-05, 0.00014941, 0.00010377, -3.0199e-06, -7.3905e-06, 0.00010116], [0.00021970, 2.3761e-06, -1.7259e-05, 2.4419e-05, 0.00077828, 1.7926e-05, 0.00011255, -8.7346e-06, 0.00025089, 1.4888e-05, 0.00010471, 2.7662e-05, -0.02087439, 0.00120961, 0.00077754, 0.00191142, 7.6885e-05, -1.4264e-06, 7.4781e-06, 6.0229e-06, 1.4661e-05, 2.2174e-06, 3.775e-06, -4.1747e-06, 2.7901e-05, 1.3432e-05, -1.661e-05, -3.7729e-05, 0.00108702, 2.813e-05, 1.9609e-05, 8.0565e-05, 9.8153e-05, 1.261e-05, -6.1823e-06, 2.5881e-06, 0.00013990, -8.2843e-07, 3.5387e-05, 1.7534e-05, 1.0915e-05, 1.4834e-06, 6.5955e-06, -1.0667e-05, 0.00254463, 5.2962e-05, 0.00018903, 0.00016103, 0, 9.8918e-07, 0, 3.2392e-05, 4.3559e-05, 2.5942e-06, 2.0588e-06, -3.5828e-06, 0, 1.1313e-05, 6.638e-06, -1.2045e-07, 0.00094155, 3.3734e-05, 0.00017871, 4.6047e-05], [-6.7541e-06, 0.00012497, 1.3058e-05, 1.8521e-05, 3.5385e-05, 0.00051719, 7.5885e-05, 0.00010109, 4.4034e-06, 0.00018385, 4.4286e-05, 2.4713e-06, 0.00353120, -0.00983742, 0.00032066, 0.00433281, 1.3066e-05, 4.3262e-05, -1.2321e-06, 2.5955e-06, 3.5412e-06, 9.4135e-05, -9.9069e-06, -1.1216e-05, 6.8293e-07, 3.6239e-05, 1.4455e-05, -5.8911e-06, 1.3406e-05, 0.00059662, 8.2468e-05, 0.00012072, 6.1173e-06, 4.2558e-05, 1.185e-06, 7.2045e-06, 2.3737e-06, 0.00010011, -9.9883e-06, -5.1856e-06, 1.2868e-06, 2.2693e-05, -1.9726e-07, -2.7908e-06, 5.4905e-05, 0.00128621, 0.00023418, 0.00060634, 0, 9.0164e-05, 0, -3.5999e-06, 8.0956e-06, 1.7288e-05, -4.5323e-06, 9.8302e-06, 0, 3.8901e-05, 1.0102e-07, 1.6191e-06, 0.00010050, 0.00025451, 0.00015432, 2.497e-05], [1.6507e-05, 3.7883e-05, 9.4915e-05, 5.4659e-05, 0.00017405, 8.253e-05, 0.00067245, 9.5052e-05, -4.5786e-08, 3.6451e-05, 0.00020157, 4.126e-05, 0.00249433, 0.00035226, -0.00577373, 0.00046259, 1.4449e-05, 1.9057e-05, 4.2157e-05, 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